Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes
K. Dave, D. B. Stolz, V. R. Venna, V. A. Quaicoe, M. E. Maniskas, M. J. Reynolds, R. Babidhan, D. X. Dobbins, M. N. Farinelli, A. Sullivan, T. N. Bhatia, H. Yankello, R. Reddy, Y. Bae, R. K. Leak, , D. Soundara Manickam
This paper shows that medium-to-large extracellular vesicles (m/lEVs) protect brain endothelial cells by transferring mitochondria and reducing brain infarct sizes in a mouse stroke model.
bioRxiv · Oct 29, 2021Bioengineering