M. J. Reynolds

Fascin structural plasticity mediates flexible actin bundle construction

This study investigates how fascin's structural plasticity enables flexible actin bundle formation through cryo-EM, tomography, and modeling.

Actin nucleotide state modulates the F-actin structural landscape evoked by bending forces

This study shows bending forces induce structural changes in F-actin that depend on its nucleotide state, with phosphate stabilizing subunit conformations and altering the structural landscape.

Structural mechanism for bi-directional actin crosslinking by T-plastin

Cryo-EM, biochemical, and cellular studies reveal how the crosslinking protein T-plastin bridges actin filaments in two opposing orientations.

Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes

This paper shows that medium-to-large extracellular vesicles (m/lEVs) protect brain endothelial cells by transferring mitochondria and reducing brain infarct sizes in a mouse stroke model.

Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia

This paper presents cryo-EM structures of myosin-15 bound to F-actin, revealing how mutations affect actin polymerization and stereocilia elongation.

Molecular mechanism for direct actin force-sensing by α-catenin

This study shows that force on F-actin enhances E-catenin binding but not vinculin, revealing a modular mechanism for force-sensing by α-catenin.

PRC2 bridges non-adjacent nucleosomes to establish heterochromatin

This study investigates how PRC2 interacts with chromatin using single-molecule force spectroscopy and simulations, revealing new binding configurations and their regulation.