Neutrophils regulate ITPR2 levels in epithelia by direct injection of elastase
N. Ogino, M. F. Leite, E. Kruglov, H. Asashima, D. A. Hafler, B. E. Ehrlich, M. Nathanson
The paper shows neutrophils inject elastase into hepatocytes, reducing ITPR2 levels and calcium signals without damaging cells, and identifies a compensatory response in liver biopsies.
bioRxiv · Sep 13, 2022 · PreprintCell Biology