Regulation of FGF/MAPK signaling at the primary cilium base controls the proliferation-neurogenesis balance in human cerebellar organoids
Ludovica Brunetti, Antonia Wiegering, Isabelle Anselme, M. Ngoc Vu, Lidia Pollara, Marie Grappin, Martin Catala, Olivier Saulnier, Christophe Antoniewski, Enza Maria Valente, Sylvie Schneider‐Maunoury, Christine Vesque
This study shows that ciliary dysfunction in human cerebellar organoids leads to overactivation of FGF/MAPK signaling, impairing neurogenesis and increasing progenitor proliferation.
bioRxiv · Apr 14, 2025 · PreprintDevelopmental Biology