Christine Vesque

Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

The paper investigates body axis development in Clytia hemisphaerica embryos, revealing a coordination mechanism between Wnt/β-catenin signaling and planar cell polarity to direct morphogenesis.

Regulation of FGF/MAPK signaling at the primary cilium base controls the proliferation-neurogenesis balance in human cerebellar organoids

This study shows that ciliary dysfunction in human cerebellar organoids leads to overactivation of FGF/MAPK signaling, impairing neurogenesis and increasing progenitor proliferation.

Astrogliosis And Neuroinflammation Underlie Scoliosis Upon Cilia Dysfunction

This study identifies astrogliosis and neuroinflammation as pathogenic mechanisms underlying scoliosis in zebrafish caused by cilia dysfunction.

PLANAR POLARIZATION OF CILIA IN THE ZEBRAFISH FLOOR PLATE INVOLVES Par3-MEDIATED POSTERIOR LOCALIZATION OF HIGHLY MOTILE BASAL BODIES.

Loss of the Reissner Fiber and increased URP neuropeptide signaling underliescoliosis in a zebrafish ciliopathy mutant