Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle length
K. Tsuchiya, H. Hayashi, M. Nishina, M. Okumura, Y. Sato, M. Kanemaki, G. Goshima, T. Kiyomitsu
This study shows that Ran-GTP is not essential for NuMA activation in spindle pole focusing but is required for HURP polarization and spindle length regulation during prometaphase.
bioRxiv · Apr 23, 2020 · PreprintCell Biology