Author

T. Kiyomitsu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Goshima· 2 shared M. Okumura· 2 shared A. Gooch· 1 shared A. Ito· 1 shared E. A. Tungadi· 1 shared H. Hayashi· 1 shared K. Tsuchiya· 1 shared M. Kanemaki· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

G. Goshima

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Author profile →

4 papers

Recent·Most cited

NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles

M. v. Toorn, A. Gooch, S. Boerner, T. Kiyomitsu

This study shows NuMA deficiency causes micronuclei through k-fiber minus-end detachment from spindle poles, which bypasses the mitotic checkpoint and leads to genomic instability.

bioRxiv · Oct 4, 2022Cell Biology

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle length

K. Tsuchiya, H. Hayashi, M. Nishina, M. Okumura, Y. Sato, M. Kanemaki, G. Goshima, T. Kiyomitsu

This study shows that Ran-GTP is not essential for NuMA activation in spindle pole focusing but is required for HURP polarization and spindle length regulation during prometaphase.

bioRxiv · Apr 23, 2020 · PreprintCell Biology

Optogenetic reconstitution reveals that Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

M. Okumura, T. Natsume, M. T. Kanemaki, T. Kiyomitsu

This study uses optogenetic reconstitution to show that NuMA clusters Dynein-Dynactin to generate cortical spindle-pulling forces through multi-arm interactions.

bioRxiv · Mar 6, 2018Cell Biology

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2

E. A. Tungadi, A. Ito, T. Kiyomitsu, G. Goshima

This study shows that human ASPM and CDK5RAP2 redundantly function in spindle pole organisation during mitosis, with ASPM depletion alone not affecting spindle morphology but causing defects when CDK5RAP2 is also depleted.

bioRxiv · Jul 29, 2017Cell Biology