M. Yamada

Glutathione supersulphide regulates T-cell receptor signalling

This study shows that glutathione supersulphide regulates T-cell receptor signalling by interacting with the CD3ε chain, affecting TCR activation and inflammation.

RGF1 controls PLT2 protein stability through ROS-dependent regulation of a cysteine residue in root meristem development

This study identifies that RGF1 regulates PLT2 protein stability via ROS-dependent modification of a cysteine residue, affecting root meristem development.

Actin binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II

The paper shows that the Rng2CHD domain inhibits actin filament motility on myosin II at low binding ratios, suggesting it modulates actin-myosin interactions through structural changes.

Childhood cancer mutagenesis caused by a domesticated DNA transposase

This study identifies PGBD5 as a primary mutator in medulloblastoma by showing it drives somatic DNA rearrangements in cerebellar progenitor cells.

Reconstituted depolarization-induced Ca2+ release platform for skeletal muscle disease mutation validation and drug discovery

The paper establishes a reconstituted DICR platform in HEK293 cells to validate skeletal muscle disease mutations and test drug candidates.

Chemical screen of Arabidopsis zygote and proteomics in tobacco BY-2 cells identify general plant cell division inhibitors

The paper identifies two plant cell division inhibitors through chemical screening in Arabidopsis zygotes and validates their effects in tobacco BY-2 cells and multiple plant species.

New insights on the role of HCN in root hair elongation through single cell proteomics

The paper uses single cell proteomics to show that S-cyanylation modifies proteins involved in root hair development in Arabidopsis.

Fast and ultra-sensitive glycoform analysis by supercritical fluid chromatography-tandem mass spectrometry

This study develops a fast, sensitive SFC-MS/MS method to analyze glycoforms of therapeutic mAbs, detecting 102 glycoforms with a 5 attomole limit and a 6-order dynamic range.

Adhesion to type I collagen fibrous gels induces E- to N- cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549

This study shows that A549 lung cancer cells cultured on type I collagen gels switch from E-cadherin to N-cadherin without other epithelial-mesenchymal transition features.

Estimating maximum sustainable yield of snow crab (Chionoecetes opilio) off Tohoku Japan via a state-space assessment model with time-varying natural mortality

The paper estimates the maximum sustainable yield of snow crab using a state-space model, finding that natural mortality and terminal molting probabilities have increased over time, affecting MSY estimates.

Novel roles of Kinesin-13 and Kinesin-8 during cell growth and division in the moss Physcomitrella patens

This study identifies divergent roles of Kinesin-13 and Kinesin-8 in microtubule dynamics, mitotic spindle formation, and tip cell growth in the moss Physcomitrella patens.

Moss Kinesin-14 KCBP accelerates chromatid motility in anaphase

This study identifies the FERM domain of moss KCBP as essential for nuclear and chloroplast positioning, and shows KCBP binds chromosomes during anaphase for their transport.

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

Antibacterial effects of nanoimprinted moth-eye film in practical settings

This study verifies that a moth-eye film with nanoscale protrusions reduces bacterial counts compared to flat and PET films in practical settings.

KCH kinesin drives nuclear transport and cytoskeletal coalescence for tip cell growth

This study identifies KCH as a kinesin-14 family member in moss that drives nuclear transport and cytoskeletal coalescence, essential for tip cell growth.

Multiple kinesin-14 family members drive microtubule minus-end-directed transport in plant cells

The paper identifies two kinesin-14 family members in plants that drive minus-end-directed transport of membranous cargoes, compensating for the absence of dynein.