Author

M. Nobles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Tinker· 2 shared A. B. Meier· 1 shared A. Goedel· 1 shared A. Kowala· 1 shared A. Moretti· 1 shared A. Paredes-Redondo· 1 shared C. Morera· 1 shared D. Ortmann· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

A. Tinker

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Author profile →

2 papers

Recent·Most cited

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

D. Zawada, J. Kornherr, A. B. Meier, G. Santamaria, T. Dorn, D. Ortmann, M. Lachmann, M. Ortiz, S. C. Harmer, M. Nobles, A. Tinker, R. A. Pedersen, P. Grote, K.-L. Laugwitz, A. Moretti, A. Goedel

This study shows that modulating retinoic acid signaling in human pluripotent stem cells generates heart field-specific progenitors, including a novel juxta-cardiac field, and identifies transcriptional dysregulation in a patient with hypoplastic left heart syndrome.

bioRxiv · May 30, 2022Cell Biology

CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model

C. Morera, J. Kim, A. Paredes-Redondo, M. Nobles, D. Rybin, R. Moccia, A. Kowala, J. Meng, S. Garren, P. Liu, J. E. Morgan, F. Muntoni, N. Christoforou, J. Owens, A. Tinker, Y.-Y. Lin

This study uses CRISPR to correct dystrophin mutations in DMD patient-derived PSCs, revealing impaired Ca2+ handling and showing rescue through gene correction.

bioRxiv · Feb 17, 2022Cell Biology