Author

M. O'Riordan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. H. Abuaita· 3 shared A.-L. E. Lawrence· 2 shared B. Bons· 2 shared C. E. Wobus· 2 shared C. Fields· 2 shared D. R. Hill· 2 shared J. R. Spence· 2 shared M.-E. Charbonneau· 2 shared

Activity by Year

2018-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

B. H. Abuaita

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Macrophage aggresome-like induced structures are flexible organizing platforms for immune signaling

M.-E. Charbonneau, V. Raghunathan, M. O'Riordan

The paper shows that macrophages form ubiquitin-containing ring-shaped structures in response to microbial stimuli, which act as adaptable platforms for immune signaling.

bioRxiv · Nov 30, 2020 · PreprintImmunology

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids

B. H. Abuaita, A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

bioRxiv · Nov 25, 2020 · PreprintMicrobiology

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system

A.-L. E. Lawrence, B. H. Abuaita, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

bioRxiv · Oct 5, 2020Microbiology

The branched chain aminotransferase IlvE promotes growth, stress resistance, and pathogenesis of Listeria monocytogenes

K. D. Passalacqua, T. Zhou, T. A. Washington, B. H. Abuaita, A. L. Sonenshein, M. O'Riordan

This study shows that IlvE promotes Listeria monocytogenes growth, stress resistance, and virulence by facilitating branched chain fatty acid synthesis and Ile-dependent pathways.

bioRxiv · Jan 31, 2020 · PreprintMicrobiology

Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses

M.-E. Charbonneau, K. Passalacqua, S. Hagen, H. Showalter, C. Wobus, M. O'Riordan

This study shows that disrupting ubiquitin homeostasis in macrophages increases reactive oxygen species production, enhancing anti-infective capacity through NOX2 and calcium signaling.

bioRxiv · Mar 5, 2018Immunology