Author

B. H. Abuaita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:metabolism & bioenergetics· 3

Frequent Co-Authors

A.-L. E. Lawrence· 4 shared C. E. Wobus· 4 shared J. S. Knight· 4 shared M. X. O'Riordan· 4 shared B. Bons· 3 shared C. Fields· 3 shared D. R. Hill· 3 shared J. R. Spence· 3 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersImmunology

A.-L. E. Lawrence

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The IRE1α-XBP1 signaling axis promotes glycolytic reprogramming in response to inflammatory stimuli

B. C. English, H. P. Savage, S. P. Mahan, V. E. Diaz-Ochoa, B. M. Young, B. H. Abuaita, G. J. Sule, J. S. Knight, M. X. O'Riordan, A. J. Baumler, R. M. Tsolis

This study shows that the IRE1α-XBP1 signaling axis enhances glycolysis in macrophages during inflammation, but pathway activation alone is not sufficient to increase glycolytic rates.

bioRxiv · Oct 19, 2022Immunology

Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, J. S. Knight, C. E. Wobus, J. R. Spence, V. B. Young, B. H. Abuaita, M. X. O'Riordan

This study investigates how human neutrophils modulate host responses to two nontyphoidal Salmonella serovars using intestinal organoids and transcriptomics.

bioRxiv · Aug 9, 2022 · PreprintImmunology

Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II assembly and stability

M. B. Reynolds, H. S. Hong, B. C. Michmerhuizen, A.-L. E. Lawrence, L. Zhang, J. S. Knight, C. A. Lyssiotis, B. H. Abuaita, M. X. O'Riordan

The paper shows cardiolipin regulates Complex II assembly and stability in macrophages, linking it to inflammatory metabolic reprogramming.

bioRxiv · Jul 27, 2022 · PreprintImmunology

Human norovirus infection of primary B cells triggers immune activation in vitro

C. Mirabelli, M. K. Jones, V. Young, A. Kolawole, I. Owusu, M. Shan, B. H. Abuaita, I. Grigorova, S. K. Lundy, C. A. Lyssiotis, V. K. Ward, S. M. Karst, C. E. Wobus

This study shows human norovirus infects primary B cells, induces functional changes, and the NS1 protein affects B cell proliferation and metabolism in vitro.

bioRxiv · May 14, 2021 · PreprintMicrobiology

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids

B. H. Abuaita, A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

bioRxiv · Nov 25, 2020 · PreprintMicrobiology

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system

A.-L. E. Lawrence, B. H. Abuaita, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

bioRxiv · Oct 5, 2020Microbiology

The branched chain aminotransferase IlvE promotes growth, stress resistance, and pathogenesis of Listeria monocytogenes

K. D. Passalacqua, T. Zhou, T. A. Washington, B. H. Abuaita, A. L. Sonenshein, M. O'Riordan

This study shows that IlvE promotes Listeria monocytogenes growth, stress resistance, and virulence by facilitating branched chain fatty acid synthesis and Ile-dependent pathways.

bioRxiv · Jan 31, 2020 · PreprintMicrobiology

The IRE1α stress signaling axis is a key regulator of neutrophil antimicrobial effector function

B. H. Abuaita, G. J. Sule, T. L. Schultz, F. Gao, J. S. Knight, M. X. O'Riordan

The paper shows that IRE1α activation enhances neutrophil antimicrobial functions like IL-1β production, NET formation, and MRSA killing.

bioRxiv · Aug 22, 2019Immunology