Author

D. R. Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Assay:organoid / primary culture· 2 Organism:E. coli· 1

Frequent Co-Authors

S. Huang· 5 shared V. K. Yadagiri· 5 shared A.-L. E. Lawrence· 4 shared B. Bons· 4 shared C. E. Wobus· 4 shared C. Fields· 4 shared J. R. Spence· 4 shared R. P. Berger· 4 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

S. Huang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, J. S. Knight, C. E. Wobus, J. R. Spence, V. B. Young, B. H. Abuaita, M. X. O'Riordan

This study investigates how human neutrophils modulate host responses to two nontyphoidal Salmonella serovars using intestinal organoids and transcriptomics.

bioRxiv · Aug 9, 2022 · PreprintImmunology

Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during Salmonella infection

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, G. J. Sule, J. S. Knight, C. E. Wobus, J. Spence, V. Young, M. X. O'Riordan, B. Abuaita

This study shows human neutrophils enhance intestinal epithelial cell extrusion to reduce Salmonella burden during infection, beyond direct antimicrobial activity.

bioRxiv · Mar 25, 2022Microbiology

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids

B. H. Abuaita, A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

bioRxiv · Nov 25, 2020 · PreprintMicrobiology

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system

A.-L. E. Lawrence, B. H. Abuaita, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

bioRxiv · Oct 5, 2020Microbiology

Loss of RpoS results in attenuated Escherichia coli colonization of human intestinal organoids and a competitive disadvantage within the germ-free mouse intestine

M. R. Barron, R. J. Cieza, D. R. Hill, S. Huang, V. K. Yadagiri, J. R. Spence, V. B. Young

This study shows that E. coli lacking RpoS has reduced colonization ability in human intestinal organoids but not in germ-free mice, indicating different stress environments in these models.

bioRxiv · Jul 30, 2020 · PreprintMicrobiology