Author

R. Penn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. D. Davidson· 1 shared A. Hobbs· 1 shared B. Hanley· 1 shared B. Williams· 1 shared C. Swanton· 1 shared D. A. Matthews· 1 shared D. Greenwood· 1 shared D. H. Goldhill· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. D. Davidson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1

G. Dowgier, A. Hobbs, D. Greenwood, M. Shawe-Taylor, P. Stevenson-Leggett, J. Bazire, R. Penn, R. Harvey, V. Libri, G. Kassiotis, S. Gamblin, N. S. Lewis, B. Williams, C. Swanton, S. Gandhi, , M. Y. Wu

The paper evaluates neutralising antibody titres against SARS-CoV-2 variant JN.1 using live-virus microneutralisation assays in vaccinated individuals, finding higher titres in monovalent vaccine recipients.

bioRxiv · Apr 17, 2024 · PreprintMicrobiology

Primary human macrophages exhibit a modest inflammatory response early in SARS-CoV-2 infection

Z. Zhang, R. Penn, W. S. S. Barclay, E. S. Giotis

This study shows that primary human macrophages do not support SARS-CoV-2 replication and exhibit a limited cytokine response, unlike influenza viruses which induce strong IFN-β and proinflammatory cytokines.

bioRxiv · Feb 2, 2022 · PreprintMicrobiology

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells.

T. P. Peacock, D. H. Goldhill, J. Zhou, L. Baillon, R. Frise, O. C. Swann, R. Kugathasan, R. Penn, J. C. Brown, R. Y. Sanchez-David, L. Braga, M. K. Williamson, J. A. Hassard, E. Staller, B. Hanley, , W. S. Barclay

This study shows the furin cleavage site in SARS-CoV-2 spike protein enhances replication in airway cells, contributing to transmission efficiency.

bioRxiv · Sep 30, 2020 · PreprintMicrobiology