A paracrine circuit of IL-1b/IL-1R1 between myeloid and tumor cells drives glioblastoma progression
Z. Chen, B. Giotti, M. Kaluzova, C. Herting, G. Pinero, m. p. vallcorba, S. Cristea, J. L. Ross, J. Ackley, V. Maximov, F. Szulzewsky, M. Marquez-Ropero, A. Angione, N. Nichols, N. Tsankkova, , D. Hambardzumyan
The paper identifies a paracrine IL-1β/IL-1R1 circuit between myeloid and tumor cells that drives glioblastoma progression and shows that antagonizing this circuit reduces tumor growth and extends survival.
bioRxiv · Apr 3, 2022 · PreprintCancer Biology