Author

A. M. Tsankov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

B. Giotti· 4 shared A. Regev· 2 shared D. H. Gutmann· 2 shared D. Hambardzumyan· 2 shared G. Pinero· 2 shared J. L. Ross· 2 shared M. Slyper· 2 shared O. Rozenblatt-Rosen· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCancer Biology

B. Giotti

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

A. Waghray, I. Monga, B. Lin, V. Shah, M. Slyper, B. Giotti, J. Xu, J. Waldman, D. Dionne, L. T. Nguyen, W. Lou, P. Cai, E. Park, C. Muus, J. Sun, , J. Rajagopal

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

A cellular and spatial atlas of TP53-associated tissue remodeling in lung adenocarcinoma

W. Zhao, B. Kepecs, N. R. Mahadevan, A. Segerstolpe, J. L. Weirather, N. R. Besson, B. Giotti, B. Y. Soong, C. Li, S. Vigneau, M. Slyper, I. Wakiro, J. Jane-Valbuena, O. Ashenberg, A. Rotem, , A. M. Tsankov

This study constructs a multi-omic atlas of TP53-mutant lung adenocarcinoma tumors, revealing altered cellular identity, gene expression programs, and spatial interactions in the tumor microenvironment.

bioRxiv · Jun 28, 2023 · PreprintCancer Biology

The novel compensatory reciprocal interplay between neutrophils and monocytes drives cancer progression

Z. Chen, N. Soni, G. Pinero, B. Giotti, D. J. Eddins, K. E. Lindblad, J. L. Ross, N. Tsankova, D. H. Gutmann, S. Lira, A. Lujambio, E. E. B. Ghosn, A. M. Tsankov, D. Hambardzumyan

This paper shows that eliminating monocyte chemoattraction increases neutrophil infiltration in glioblastoma, promoting tumor aggression, and that targeting both monocytes and neutrophils improves survival in mouse models.

bioRxiv · Jul 21, 2022 · PreprintImmunology

A paracrine circuit of IL-1b/IL-1R1 between myeloid and tumor cells drives glioblastoma progression

Z. Chen, B. Giotti, M. Kaluzova, C. Herting, G. Pinero, m. p. vallcorba, S. Cristea, J. L. Ross, J. Ackley, V. Maximov, F. Szulzewsky, M. Marquez-Ropero, A. Angione, N. Nichols, N. Tsankkova, , D. Hambardzumyan

The paper identifies a paracrine IL-1β/IL-1R1 circuit between myeloid and tumor cells that drives glioblastoma progression and shows that antagonizing this circuit reduces tumor growth and extends survival.

bioRxiv · Apr 3, 2022 · PreprintCancer Biology