Muscle weakness precedes atrophy during cancer cachexia and is associated with muscle-specific mitochondrial stress
L. J. Delfinis, C. A. Bellissimo, S. Gandhi, S. N. DiBenedetto, M. E. Rosa-Caldwell, F. A. Rahman, M. P. Wiggs, U. Schlattner, J. Quadrilatero, N. P. Greene, C. G. R. Perry
This study shows muscle weakness occurs before atrophy in mice with cancer cachexia and is linked to muscle-specific mitochondrial changes.
bioRxiv · Sep 15, 2021 · PreprintPhysiology