S. Gandhi

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

Azadirachta indica: derived, red-emitting, carbon nanoparticles for cellular bioimaging and potential therapeutics

This paper synthesizes red-emitting carbon nanoparticles from neem leaves and evaluates their cellular uptake and biocompatibility for bioimaging and therapeutic applications.

RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds

RASP detects fluorescent puncta in complex cellular backgrounds with high precision and speed, outperforming existing methods by using image gradients to separate objects from noise.

Cardiac atrophy, dysfunction, and metabolic impairments: a cancer-induced heart failure phenotype

This study shows that cancer causes cardiac atrophy, dysfunction, and metabolic changes similar to heart failure in mouse models.

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

The adiponectin analogue ALY688-SR attenuates diaphragm fibrosis, atrophy and mitochondrial stress in a mouse model of Duchenne muscular dystrophy

This paper shows that ALY688-SR reduces diaphragm fibrosis and atrophy in DMD mice by lowering mitochondrial stress, but not in tibialis anterior.

Emergence of new subgenomic mRNAs in SARS-CoV-2

This study identifies new subgenomic mRNAs in SARS-CoV-2 arising from mutations that create novel transcription regulatory sequences, leading to the expression of functional proteins like N.iORF3.

Deep learning in human neurons predicts mechanistic subtypes of Parkinson's

This study uses deep learning on patient-derived neurons to predict Parkinson's disease subtypes with high accuracy, highlighting mitochondrial and lysosomal features as key predictors.

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

Muscle weakness precedes atrophy during cancer cachexia and is associated with muscle-specific mitochondrial stress

This study shows muscle weakness occurs before atrophy in mice with cancer cachexia and is linked to muscle-specific mitochondrial changes.

Mitotic H3K9ac is controlled by phase-specific activity of HDAC2, HDAC3 and SIRT1

The paper identifies HDAC2, HDAC3, and SIRT1 as regulators of H3K9ac during mitosis, showing phase-specific effects on acetylation levels in different mitotic stages.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.

eCovSens-Ultrasensitive Novel In-House Built Printed Circuit Board Based Electrochemical Device for Rapid Detection of nCovid-19 antigen, a spike protein domain 1 of SARS-CoV-2

This paper develops an in-house biosensor (eCovSens) for rapid detection of SARS-CoV-2 spike antigen in saliva, showing comparable sensitivity to a commercial potentiostat.