Author

L. J. Delfinis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

S. Gandhi· 4 shared M. C. Garibotti· 3 shared C. A. Bellissimo· 2 shared C. G. Perry· 2 shared J. A. Simpson· 2 shared J. Petrik· 2 shared K. Matuszewska· 2 shared L. M. Ogilvie· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersPhysiology

S. Gandhi

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4 papers

Recent·Most cited

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

L. J. Delfinis, L. M. Ogilvie, S. Khajehzadehshoushtar, S. Gandhi, M. C. Garibotti, A. K. Thuhan, K. Matuszewska, M. Pereira, R. G. Jones, A. J. Cheng, T. J. Hawke, N. P. Greene, K. Murach, J. A. Simpson, J. Petrik, C. Perry

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

bioRxiv · Apr 8, 2024 · PreprintPhysiology

Cardiac atrophy, dysfunction, and metabolic impairments: a cancer-induced heart failure phenotype

L. M. Ogilvie, L. J. Delfinis, B. Coyle-Asbil, V. Vudatha, R. Alshamali, B. Garlisi, M. Pereira, K. Matuszewska, M. C. Garibotti, S. Gandhi, K. R. Brunt, J. G. Trevino, C. G. Perry, J. Petrik, J. A. Simpson

This study shows that cancer causes cardiac atrophy, dysfunction, and metabolic changes similar to heart failure in mouse models.

bioRxiv · Sep 30, 2023 · PreprintPhysiology

The adiponectin analogue ALY688-SR attenuates diaphragm fibrosis, atrophy and mitochondrial stress in a mouse model of Duchenne muscular dystrophy

C. A. Bellissimo, S. Gandhi, L. N. Castellani, M. Murugathasan, L. J. Delfinis, A. Thuhan, M. C. Garibotti, Y. Seo, I. A. Rebalka, G. Sweeney, T. J. Hawke, A. A. Abdul-Sater, C. G. Perry

This paper shows that ALY688-SR reduces diaphragm fibrosis and atrophy in DMD mice by lowering mitochondrial stress, but not in tibialis anterior.

bioRxiv · May 22, 2023 · PreprintPhysiology

Muscle weakness precedes atrophy during cancer cachexia and is associated with muscle-specific mitochondrial stress

L. J. Delfinis, C. A. Bellissimo, S. Gandhi, S. N. DiBenedetto, M. E. Rosa-Caldwell, F. A. Rahman, M. P. Wiggs, U. Schlattner, J. Quadrilatero, N. P. Greene, C. G. R. Perry

This study shows muscle weakness occurs before atrophy in mice with cancer cachexia and is linked to muscle-specific mitochondrial changes.

bioRxiv · Sep 15, 2021 · PreprintPhysiology