A cell-topography based mechanism for ligand discrimination by the T-cell receptor
R. A. Fernandes, K. A. Ganzinger, J. Tzou, P. Jonsson, S. F. Lee, M. Palayret, A. M. Santos, A. A. Carr, A. Ponjavic, V. T. Chang, C. Macleod, B. C. Lagerholm, A. E. Lindsay, O. Dushek, A. Tilevik, , D. Klenerman
This paper develops a model showing T-cell receptors discriminate ligands based on dwell-time in phosphatase-depleted contacts constrained by cell topography, predicting signaling potency without multi-step proof-reading.
bioRxiv · Nov 19, 2018Immunology