Author

J. Kawahara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

A. Zani· 3 shared A. Eddy· 2 shared A. Forero· 2 shared A. Kenney· 2 shared C. Cai· 2 shared J. Li· 2 shared J. Ma· 2 shared J. S. Yount· 2 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. Zani

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Author profile →

3 papers

Recent·Most cited

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

A. Zani, A. Kenney, J. Kawahara, A. C. Eddy, X.-L. Wang, M. KC, M. Lu, E. A. Hemann, J. Li, M. E. Peeples, L. Hall-Stoodley, A. Forero, C. Cai, J. Ma, J. S. Yount

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

bioRxiv · Dec 22, 2021 · PreprintImmunology

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

A. D. Kenney, S. L. Aron, C. Gilbert, N. Kumar, P. Chen, A. Eddy, L. Zhang, A. Zani, N. Vargas-Maldonado, S. Speaks, J. Kawahara, P. J. Denz, L. Dorn, F. Accornero, J. Ma, , J. S. Yount

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

bioRxiv · Oct 27, 2021Immunology

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

M. Eltobgy, A. Zani, A. Kenney, S. Estfanous, E. Kim, A. Badr, C. Carafice, K. Daily, O. Whitham, M. Pietrzak, A. Webb, J. Kawahara, A. Eddy, P. Denz, M. Lu, , A. Amer

This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.

bioRxiv · Sep 24, 2021Immunology