Author

R. F. Hwang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Ludwig· 1 shared A. W. Dangel· 1 shared A. Webb· 1 shared B. Rostandy· 1 shared D. Bar-Sagi· 1 shared E. De Stanchina· 1 shared H. Alwaseem· 1 shared H. Molina· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Ludwig

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Author profile →

2 papers

Recent·Most cited

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

J. Garcia-Bermudez, S. Prasad, L. Baudrier, M. A. Badgley, Y. Liu, K. La, M. Soula, R. T. Williams, N. Yamaguchi, R. F. Hwang, L. J. Taylor, E. De Stanchina, B. Rostandy, H. Alwaseem, H. Molina, , K. Birsoy

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

bioRxiv · Feb 2, 2021Cancer Biology

Iron and lipocalin-2 modulate cellular responses in the tumor micro-environment of pancreatic ductal adenocarcinoma

V. Pita-Grisanti, A. W. Dangel, K. Gumpper, A. Ludwig, O. Ueltschi, X. M. Mo, M. Pietrzak, A. Webb, R. F. Hwang, M. Traczek, N. Badi, Z. Cruz-Monserrate

This study shows that iron and lipocalin-2 (LCN2) influence PDAC cell behavior and metastasis, with LCN2 deletion reducing metastasis and iron chelation increasing anti-metastatic gene expression.

bioRxiv · Jan 14, 2020 · PreprintCancer Biology