Author

H. Mostafavi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant effect prediction· 2 Approach:experimental assay· 1 Assay:GWAS summary statistics· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:polygenic risk· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

J. K. Pritchard· 2 shared A. Harpak· 1 shared A. K. Lagendijk· 1 shared A. M. Joergensen· 1 shared B. Hill· 1 shared C. J. Stocks· 1 shared C. L. Holley· 1 shared C. M. Nefzger· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersEvolutionary Biology

J. K. Pritchard

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Author profile →

4 papers

Recent·Most cited

Scaling the Discrete-time Wright Fisher model to biobank-scale datasets

J. P. Spence, T. Zeng, H. Mostafavi, J. K. Pritchard

This paper introduces an algorithm to scale the Discrete-Time Wright Fisher model to large datasets, enabling efficient and accurate population genetic inference at biobank scale.

bioRxiv · May 19, 2023Evolutionary Biology

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

L. I. Labzin, K. Y. Chew, K. Eschke, X. Wang, T. Esposito, C. J. Stocks, J. Rae, R. Patrick, H. Mostafavi, B. Hill, T. Yordanov, C. L. Holley, S. Emming, S. Fritzlar, F. L. Mordant, , K. Schroder

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Reduced signal for polygenic adaptation of height in UK Biobank

J. J. Berg, A. Harpak, N. Sinnott-Armstrong, A. M. Joergensen, H. Mostafavi, Y. Field, E. A. Boyle, X. Zhang, F. Racimo, J. K. Pritchard, G. Coop

The paper analyzes polygenic height scores from UK Biobank and finds reduced signals of selection compared to previous studies, suggesting potential issues with population stratification correction.

bioRxiv · Dec 10, 2018Evolutionary Biology

Identifying genetic variants that affect viability in large cohorts

H. Mostafavi, T. Berisa, F. Day, J. Perry, M. Przeworski, J. K. Pickrell

The paper identifies genetic variants affecting viability by analyzing large cohorts, finding few common variants with large effects on age-specific mortality and sex-specific differences.

bioRxiv · Jun 19, 2017Evolutionary Biology