ASCL1 represses a latent osteogenic program in small cell lung cancer in multiple cells of origin
R. R. Olsen, D. W. Kastner, A. S. Ireland, S. M. Groves, K. Pozo, C. P. Whitney, M. R. Guthrie, S. J. Wait, D. Soltero, B. L. Witt, V. Quaranta, J. E. Johnson, T. G. Oliver
This study shows ASCL1 represses a latent osteogenic program in SCLC, promoting tumor initiation and preventing differentiation into bone tumors.
bioRxiv · Nov 11, 2020Cancer Biology