Author

S. J. Wait

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

A. Berndt· 3 shared J. D. Lee· 3 shared M. Rappleye· 2 shared N. Smith· 2 shared A. Asencio· 1 shared A. Gordon-Fennel· 1 shared A. K. Matarasso· 1 shared A. Moghadasi· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBioengineering

A. Berndt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Machine Learning Ensemble Directed Engineering of Genetically Encoded Fluorescent Calcium Indicators.

S. J. Wait, M. Rappleye, J. D. Lee, N. Smith, A. Berndt

This study uses machine learning to predict and engineer improved fluorescent calcium indicators, identifying variants with faster kinetics and larger responses.

Nature Computational Science · Mar 21, 2024Peer-reviewedBioengineering

Far-red and sensitive sensor for monitoring real-time H2O2 dynamics with subcellular resolution and inmulti-parametric imaging applications.

J. D. Lee, A. Nguyen, Z. R. Jin, A. Moghadasi, C. E. Gibbs, S. J. Wait, K. M. Evitts, A. Asencio, S. B. Bremner, S. Zuniga, V. Chavan, A. Williams, N. Smith, M. Regnier, J. E. Young, , A. Berndt

This paper introduces a new fluorescent sensor, oROS-HT, for real-time H2O2 monitoring with subcellular resolution and multi-parametric imaging capabilities.

bioRxiv · Feb 6, 2024 · PreprintBioengineering

Opto-MASS: a high-throughput engineering platform for genetically encoded fluorescentsensors enabling all optical in vivo detection of monoamines and neuropeptides

M. Rappleye, A. Gordon-Fennel, D. C. Castro, A. K. Matarasso, C. A. Zamorano, C. Stine, S. J. Wait, J. D. Lee, J. D. Siebart, A. Suko, N. C. Smith, J. Muster, K. A. Matreyek, D. M. Fowler, G. D. Stuber, , A. Berndt

The paper introduces Opto-MASS, a high-throughput platform for engineering fluorescent sensors to detect monoamines and neuropeptides in vivo by screening thousands of variants in mammalian cells.

bioRxiv · Jun 1, 2022 · PreprintBioengineering

ASCL1 represses a latent osteogenic program in small cell lung cancer in multiple cells of origin

R. R. Olsen, D. W. Kastner, A. S. Ireland, S. M. Groves, K. Pozo, C. P. Whitney, M. R. Guthrie, S. J. Wait, D. Soltero, B. L. Witt, V. Quaranta, J. E. Johnson, T. G. Oliver

This study shows ASCL1 represses a latent osteogenic program in SCLC, promoting tumor initiation and preventing differentiation into bone tumors.

bioRxiv · Nov 11, 2020Cancer Biology