Author

D. W. Kastner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. J. Mitchell· 1 shared A. S. Ireland· 1 shared B. L. Witt· 1 shared C. E. Albright· 1 shared C. M. Glinkerman· 1 shared C. P. Whitney· 1 shared C. Y. Kim· 1 shared D. Soltero· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. J. Mitchell

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2 papers

Recent·Most cited

Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

C. Y. Kim, A. J. Mitchell, D. W. Kastner, C. E. Albright, M. Gutierrez, C. M. Glinkerman, H. J. Kulik, J.-K. Weng

This study identifies a proton exchange-based isomerization and lactonization mechanism in the plant enzyme COSY, revealing its unique catalytic activity and evolutionary adaptation.

bioRxiv · Jul 19, 2022Biochemistry

ASCL1 represses a latent osteogenic program in small cell lung cancer in multiple cells of origin

R. R. Olsen, D. W. Kastner, A. S. Ireland, S. M. Groves, K. Pozo, C. P. Whitney, M. R. Guthrie, S. J. Wait, D. Soltero, B. L. Witt, V. Quaranta, J. E. Johnson, T. G. Oliver

This study shows ASCL1 represses a latent osteogenic program in SCLC, promoting tumor initiation and preventing differentiation into bone tumors.

bioRxiv · Nov 11, 2020Cancer Biology