Author

Y. Muroyama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. C. Huang· 2 shared D. Mathew· 2 shared S. L. Berger· 2 shared S. Manne· 2 shared A. R. Greenplate· 1 shared C. F. Friedman· 1 shared C. H. June· 1 shared C. K. Garcia· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersImmunology

A. C. Huang

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

J. C. Beltra, M. S. Abdel-Hakeem, S. Manne, Z. Zhang, H. Huang, M. Kurachi, L. Su, L. Picton, Y. Muroyama, V. Casella, Y. J. Huang, J. R. Giles, D. Mathew, J. Belman, M. Klapholz, , J. E. Wherry

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer.

Y. Muroyama, S. Manne, N. Wellhausen, D. A. Oldridge, A. R. Greenplate, L. Chilukuri, D. Mathew, C. Xu, R. S. Herati, S. L. Berger, A. C. Huang, C. H. June, D. Zamarin, C. F. Friedman, E. J. Wherry

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

bioRxiv · Apr 16, 2022 · PreprintImmunology