Author

M. Kurachi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Approach:experimental assay· 1

Frequent Co-Authors

E. J. Wherry· 2 shared H. Huang· 2 shared J. R. Giles· 2 shared S. L. Berger· 2 shared S. Manne· 2 shared Z. Zhang· 2 shared A. Battle· 1 shared A. C. Huang· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

E. J. Wherry

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

J. C. Beltra, M. S. Abdel-Hakeem, S. Manne, Z. Zhang, H. Huang, M. Kurachi, L. Su, L. Picton, Y. Muroyama, V. Casella, Y. J. Huang, J. R. Giles, D. Mathew, J. Belman, M. Klapholz, , J. E. Wherry

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Batf-mediated Epigenetic Control of Effector CD8+ T Cell Differentiation

H.-W. Tsao, J. Kaminski, M. Kurachi, R. A. Barnitz, M. A. DiIorio, M. W. LaFleur, W. Ise, T. Kurosaki, E. J. Wherry, W. N. Haining, N. Yosef

This study identifies Batf's role in regulating effector CD8+ T cell differentiation through transcriptional and epigenetic mechanisms using genome-scale profiling.

bioRxiv · Jan 4, 2021Immunology

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer

Z. Chen, E. Arai, O. Khan, Z. Zhang, S. F. Ngiow, Y. He, H. Huang, S. Manne, Z. Cao, A. E. Baxter, Z. Cai, E. Freilich, M. A. Ali, J. R. Giles, J. E. Wu, , J. Shi

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

bioRxiv · May 20, 2020 · PreprintImmunology