Author

M. S. Horwitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

I. Shanina· 4 shared I. C. Mouat· 3 shared J. R. Allanach· 3 shared L. C. Osborne· 3 shared Z. J. Morse· 3 shared G. Vorobeychik· 2 shared N. M. Fettig· 2 shared R. L. Simister· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

I. Shanina

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

N. M. Fettig, H. G. Robonson, J. R. Allanach, K. M. Davis, R. L. Simister, E. J. Wang, A. J. Sharon, Y. Jiayu, S. J. Popple, D. L. Gibson, S. A. Crowe, M. S. Horwitz, L. C. Osborne

This study shows that guar gum reduces neuroinflammation in EAE by inhibiting Th1 activation and differentiation in CD4+ T cells, independent of microbiota or short chain fatty acid changes.

bioRxiv · Aug 4, 2022Immunology

Virus Infection Causes Intestinal Dysbiosis to Promote Type 1 Diabetes Onset

Z. J. Morse, R. L. Simister, S. A. Crowe, M. S. Horwitz, L. C. Osborne

This study shows that Coxsackievirus B4 infection alters the intestinal microbiome, promoting type 1 diabetes by disrupting intestinal homeostasis and immune activation.

bioRxiv · Jul 8, 2022 · PreprintMicrobiology

Epstein-Barr virus promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

J. R. Allanach, N. M. Fettig, B. K. Hardman, V. Fan, A. R. Rosen, E. J. Goldberg, Z. J. Morse, I. Shanina, G. Vorobeychik, L. C. Osborne, M. S. Horwitz

This study shows EBV infection worsens MS in a humanized mouse model by altering T cell balance.

bioRxiv · Feb 23, 2022 · PreprintImmunology

Age-associated B cells are long-lasting effectors that restrain reactivation of latent γHV68

I. C. Mouat, I. Shanina, M. S. Horwitz

This study shows that age-associated B cells persist during latent γHV68 infection and restrain viral reactivation by producing IFNγ and TNF.

bioRxiv · Dec 29, 2021 · PreprintImmunology

Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAE

I. C. Mouat, J. R. Allanach, V. Fan, A. M. Girard, I. Shanina, G. Vorobeychik, M. S. Horwitz

This study shows that gammaherpesvirus infection expands age-associated B cells (ABCs) and primes them for pathogenic roles in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).

bioRxiv · Jul 22, 2021 · PreprintImmunology

Latent gammaherpesvirus exacerbates arthritis and requires age-associated B cells

I. C. Mouat, Z. J. Morse, I. Shanina, K. L. Brown, M. S. Horwitz

This study shows that latent gammaherpesvirus infection worsens arthritis in mice by requiring age-associated B cells.

bioRxiv · Feb 2, 2021Immunology