Author

L. C. Osborne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1

Frequent Co-Authors

M. S. Horwitz· 3 shared R. L. Simister· 3 shared S. A. Crowe· 3 shared A. J. Sharon· 2 shared B. K. Hardman· 2 shared J. R. Allanach· 2 shared N. M. Fettig· 2 shared Z. J. Morse· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

M. S. Horwitz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

N. M. Fettig, H. G. Robonson, J. R. Allanach, K. M. Davis, R. L. Simister, E. J. Wang, A. J. Sharon, Y. Jiayu, S. J. Popple, D. L. Gibson, S. A. Crowe, M. S. Horwitz, L. C. Osborne

This study shows that guar gum reduces neuroinflammation in EAE by inhibiting Th1 activation and differentiation in CD4+ T cells, independent of microbiota or short chain fatty acid changes.

bioRxiv · Aug 4, 2022Immunology

Virus Infection Causes Intestinal Dysbiosis to Promote Type 1 Diabetes Onset

Z. J. Morse, R. L. Simister, S. A. Crowe, M. S. Horwitz, L. C. Osborne

This study shows that Coxsackievirus B4 infection alters the intestinal microbiome, promoting type 1 diabetes by disrupting intestinal homeostasis and immune activation.

bioRxiv · Jul 8, 2022 · PreprintMicrobiology

Epstein-Barr virus promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

J. R. Allanach, N. M. Fettig, B. K. Hardman, V. Fan, A. R. Rosen, E. J. Goldberg, Z. J. Morse, I. Shanina, G. Vorobeychik, L. C. Osborne, M. S. Horwitz

This study shows EBV infection worsens MS in a humanized mouse model by altering T cell balance.

bioRxiv · Feb 23, 2022 · PreprintImmunology

Age related susceptibility to grey matter demyelination and neurodegeneration is associated with meningeal neutrophil accumulation in an animal model of Multiple Sclerosis

M. Zuo, N. Fettig, L.-P. Bernier, E. Possnecker, S. Spring, A. Pu, X. I. Ma, D. S. Lee, L. Ward, A. Sharma, J. Kuhle, J. G. Sled, A.-K. Probstel, B. A. MacVicar, L. C. Osborne, , V. Ramaglia

The paper shows that age-related grey matter demyelination and neurodegeneration in MS are linked to meningeal neutrophil accumulation in an animal model.

bioRxiv · Dec 23, 2021 · PreprintImmunology

STAT1-dependent tolerance of intestinal viral infection

H. A. Filyk, A. J. Sharon, N. M. Fonseca, R. L. Simister, W. Yuen, B. K. Hardman, H. G. Robinson, J. H. Seo, J. Rocha-Pereira, I. Welch, J. Neyts, S. A. Crowe, L. C. Osborne

This study identifies STAT1 as a key regulator of intestinal tolerance to a commensal virus, showing it restricts viral replication and prevents tissue damage without requiring T cell responses.

bioRxiv · Feb 13, 2020 · PreprintImmunology