Author

R. L. Simister

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:metagenomics· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1

Frequent Co-Authors

S. A. Crowe· 5 shared L. C. Osborne· 3 shared A. J. Sharon· 2 shared C. Henny· 2 shared D. A. Fowle· 2 shared F. J. Stewart· 2 shared J. B. Glass· 2 shared J. Wu· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersMicrobiology

S. A. Crowe

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

N. M. Fettig, H. G. Robonson, J. R. Allanach, K. M. Davis, R. L. Simister, E. J. Wang, A. J. Sharon, Y. Jiayu, S. J. Popple, D. L. Gibson, S. A. Crowe, M. S. Horwitz, L. C. Osborne

This study shows that guar gum reduces neuroinflammation in EAE by inhibiting Th1 activation and differentiation in CD4+ T cells, independent of microbiota or short chain fatty acid changes.

bioRxiv · Aug 4, 2022Immunology

Virus Infection Causes Intestinal Dysbiosis to Promote Type 1 Diabetes Onset

Z. J. Morse, R. L. Simister, S. A. Crowe, M. S. Horwitz, L. C. Osborne

This study shows that Coxsackievirus B4 infection alters the intestinal microbiome, promoting type 1 diabetes by disrupting intestinal homeostasis and immune activation.

bioRxiv · Jul 8, 2022 · PreprintMicrobiology

STAT1-dependent tolerance of intestinal viral infection

H. A. Filyk, A. J. Sharon, N. M. Fonseca, R. L. Simister, W. Yuen, B. K. Hardman, H. G. Robinson, J. H. Seo, J. Rocha-Pereira, I. Welch, J. Neyts, S. A. Crowe, L. C. Osborne

This study identifies STAT1 as a key regulator of intestinal tolerance to a commensal virus, showing it restricts viral replication and prevents tissue damage without requiring T cell responses.

bioRxiv · Feb 13, 2020 · PreprintImmunology

Phylogenetic and structural diversity of aromatically dense pili from environmental metagenomes

M. S. Bray, J. Wu, C. C. Padilla, F. J. Stewart, D. A. Fowle, C. Henny, R. L. Simister, K. J. Thompson, S. A. Crowe, J. B. Glass

The paper identifies diverse putative e-pilin genes from environmental metagenomes using updated aromatic density thresholds, expanding known e-pili diversity in metal-rich ecosystems.

bioRxiv · Oct 15, 2019Microbiology

Shifting microbial communities sustain multi-year iron reduction and methanogenesis in ferruginous sediment incubations

M. S. Bray, J. Wu, B. C. Reed, C. B. Kretz, K. M. Belli, R. L. Simister, C. Henny, F. J. Stewart, T. J. DiChristina, J. A. Brandes, D. A. Fowle, S. A. Crowe, J. B. Glass

This study examines how different Fe(III) oxides affect microbial communities and methane cycling in ferruginous sediments over time, showing that Fe(III) mineralogy influences methanogenesis and iron reduction.

bioRxiv · Feb 13, 2017Microbiology