M. Scherer

Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach

The paper develops and validates an LC-MS/MS method to quantify free queuine and queuosine in human plasma, finding no detectable Q but significant q levels with no gender difference.

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

CloneTracer identifies differentiation routes in AML by adding clonal resolution to single-cell RNA-seq data, revealing disease-defining compartments and therapy response mechanisms.

Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

The paper shows that dual interferon and DNA damage signaling leads to the formation of giant PML nuclear bodies that trap viral genomes and capsids, providing a multilayered antiviral defense.

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance