Author

M. Sigouros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:organoid / primary culture· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Irizarry· 2 shared A. Sboner· 2 shared J. M. Mosquera· 2 shared J. Manohar· 2 shared M. L. Martin· 2 shared O. Elemento· 2 shared B. Awuah· 1 shared B. Bhinder· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

A. Irizarry

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2 papers

Recent·Most cited

Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition.

F. P. Madorsky Rowdo, R. Martini, S. E. Ackermann, C. P. Tang, M. Tranquile, A. Irizarry, I. Us, O. Alawa, J. E. Moyer, M. Sigouros, J. Nguyen, M. A. Assaad, E. Cheng, P. S. Ginter, J. Manohar, , M. L. Martin

The paper uses CRISPR-Cas9 screens in breast cancer organoids from African ancestry patients to identify essential kinases and show synergy between EGFR and FGFR1 inhibitors.

Cancer Research · Feb 1, 2025Peer-reviewedCancer Biology

Novel co-culture strategies of tumor organoids with autologous T-cells reveal clinically relevant combinations of immune-checkpoint and targeted therapies

E. Podaza, J. Capuano, M. Al Assaad, H.-h. Kuo, G. Markowitz, A. Irizarry, H. Ravichandran, S. Ackermann, T. Kane, J. Manohar, M. Sigouros, J. Moyer, B. Bhinder, P. Chandra, M. Malbari, , M. L. Martin

The paper develops co-culture strategies of tumor organoids with autologous T-cells to screen immune-checkpoint and targeted therapy combinations.

bioRxiv · Jul 5, 2023 · PreprintImmunology