Author

J. M. Mosquera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:organoid / primary culture· 2

Frequent Co-Authors

A. Sboner· 5 shared J. Manohar· 3 shared O. Elemento· 3 shared A. Gopalan· 2 shared A. Irizarry· 2 shared B. Bhinder· 2 shared H. Beltran· 2 shared H. Ravichandran· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersCancer Biology

A. Sboner

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Author profile →

5 papers

Recent·Most cited

Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition.

F. P. Madorsky Rowdo, R. Martini, S. E. Ackermann, C. P. Tang, M. Tranquile, A. Irizarry, I. Us, O. Alawa, J. E. Moyer, M. Sigouros, J. Nguyen, M. A. Assaad, E. Cheng, P. S. Ginter, J. Manohar, , M. L. Martin

The paper uses CRISPR-Cas9 screens in breast cancer organoids from African ancestry patients to identify essential kinases and show synergy between EGFR and FGFR1 inhibitors.

Cancer Research · Feb 1, 2025Peer-reviewedCancer Biology

Novel co-culture strategies of tumor organoids with autologous T-cells reveal clinically relevant combinations of immune-checkpoint and targeted therapies

E. Podaza, J. Capuano, M. Al Assaad, H.-h. Kuo, G. Markowitz, A. Irizarry, H. Ravichandran, S. Ackermann, T. Kane, J. Manohar, M. Sigouros, J. Moyer, B. Bhinder, P. Chandra, M. Malbari, , M. L. Martin

The paper develops co-culture strategies of tumor organoids with autologous T-cells to screen immune-checkpoint and targeted therapy combinations.

bioRxiv · Jul 5, 2023 · PreprintImmunology

Harbingers of Aggressive Prostate Cancer: Precision Oncology Case Studies

J. Cyrta, D. Prandi, A. Arora, D. H. Hovelson, A. Sboner, A. Rodriguez, T. Fedrizzi, H. Beltran, D. R. Robinson, A. Gopalan, L. True, P. Nelson, B. D. Robinson, J. M. Mosquera, S. Tomlins, , M. Rubin

This study identifies molecular features of primary prostate cancer and their relation to metastasis using genomic and histopathological analysis.

bioRxiv · Nov 30, 2021 · PreprintCancer Biology

The evolution of genomic, transcriptomic, and single-cell protein markers of metastatic upper tract urothelial carcinoma

K. Ohara, A. F. Rendeiro, B. Bhinder, K. W. Eng, H. Ravichandran, D. Pisapia, A. Vosoughi, E. Fernandez, K. Shohdy, J. Manohar, S. Beg, D. Wilkes, B. Robinson, F. Khani, R. Bareja, , J. M. Mosquera

The paper examines genomic, transcriptomic, and single-cell protein markers in metastatic upper tract urothelial carcinoma, finding discordant genomic alterations but stable molecular and immune subtypes between primary and metastatic tumors.

bioRxiv · Nov 16, 2021 · PreprintCancer Biology

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

F. Tang, S. Wang, C. K. Wong, C. J. Lee, S. Cohen, J. Park, C. E. Hill, K. Eng, R. Bareja, T. Han, E. M. Liu, A. Palladino, W. Di, D. Gao, W. Abida, , E. Khurana

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology