Author

M. Sutcliffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Janes· 3 shared S. Singh· 3 shared M. A. Lancaster· 2 shared S. L. Giandomenico· 2 shared D. Schaff· 1 shared E. S. Riis· 1 shared G. A. Wray· 1 shared H. Zong· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

K. Janes

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pan-cancer Drivers are Recurrent Transcriptional Regulatory Heterogeneities in Early-stage Luminal Breast Cancer

S. Singh, M. Sutcliffe, K. Repich, K. Atkins, J. Harvey, K. Janes

The paper identifies recurrent transcriptional regulatory heterogeneities in early-stage luminal breast cancer using stochastic profiling and 10-cell RNA sequencing, revealing genes associated with EMT and pan-cancer drivers.

Cancer Research · Feb 2, 2021Peer-reviewedCancer Biology

Premalignant Nf1,Trp53-null Oligodendrocyte Precursor Cells BecomeStalled in a Heterogeneous State of Replication Stress BeforeGliomagenesis

M. Sutcliffe, R. Galvao, L. Wang, J. Kim, L. Rosenfeld, S. Singh, H. Zong, K. Janes

This study identifies replication stress in premalignant OPCs before glioma formation using stochastic profiling in a mouse model.

Cancer Research · Feb 2, 2021Peer-reviewedCancer Biology

The supramolecular landscape of growing human axons

P. C. Hoffmann, S. L. Giandomenico, I. Ganeva, M. R. Wozny, M. Sutcliffe, W. Kukulski, M. A. Lancaster

This study uses advanced imaging techniques to reveal the molecular architecture of growing human axons in cerebral organoids, highlighting structural features and functional implications.

bioRxiv · Jul 23, 2020 · PreprintCell Biology

An early cell shape transition drives evolutionary expansion of the human forebrain

S. Benito-Kwiecinski, S. L. Giandomenico, M. Sutcliffe, E. S. Riis, P. Freire-Pritchett, I. Kelava, S. Wunderlich, U. Martin, G. A. Wray, M. A. Lancaster

The paper uses cerebral organoids to show that a delayed cell shape transition in human neuroepithelial cells drives brain expansion compared to apes.

bioRxiv · Jul 4, 2020Evolutionary Biology

Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic Microenvironments

D. Schaff, S. Singh, K.-B. Kim, M. Sutcliffe, K.-S. PARK, K. Janes

This study identifies regulatory state heterogeneity in small-cell lung cancer cells in vitro and in vivo, showing increased fragmentation in the liver and its prognostic relevance in human tumors.

bioRxiv · Mar 30, 2020Cancer Biology