K. Janes

Patient-derived response estimates from zero-passage organoids of luminal breast cancer

This study develops zero-passage organoids from luminal breast cancer patient samples to test genetic and pharmacologic perturbations, finding variable hormone responsiveness and complex interactions with sulforaphane and NQO1 knockout.

Pan-cancer Drivers are Recurrent Transcriptional Regulatory Heterogeneities in Early-stage Luminal Breast Cancer

The paper identifies recurrent transcriptional regulatory heterogeneities in early-stage luminal breast cancer using stochastic profiling and 10-cell RNA sequencing, revealing genes associated with EMT and pan-cancer drivers.

Premalignant Nf1,Trp53-null Oligodendrocyte Precursor Cells BecomeStalled in a Heterogeneous State of Replication Stress BeforeGliomagenesis

This study identifies replication stress in premalignant OPCs before glioma formation using stochastic profiling in a mouse model.

Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic Microenvironments

This study identifies regulatory state heterogeneity in small-cell lung cancer cells in vitro and in vivo, showing increased fragmentation in the liver and its prognostic relevance in human tumors.

Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies

The paper identifies an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies, showing its role in stress tolerance and 3D growth.