SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodeling
S. Torices, C. S. Motta, B. G. da Rosa, A. C. Marcos, L. Alvarez-Rosa, M. Siqueira, T. Moreno-Rodriguez, A. Matos, B. Caetano, J. Martins, E. Loiola, L. Gladulich, O. R. Bagshaw, J. A. Stuart, M. M. Siqueira, , D. Adesse
This study investigates SARS-CoV-2 infection of human brain microvascular endothelial cells, finding NF-κB non-canonical pathway activation and mitochondrial remodeling contribute to neuroinflammation and BBB disruption.
bioRxiv · Jun 16, 2022 · PreprintCell Biology