Author

J. Aman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

G. Vidarsson· 2 shared H. J. Bogaard· 2 shared H.-J. Chen· 2 shared J. den Dunnen· 2 shared W. Hoepel· 2 shared A. Neele· 1 shared A. P. Bye· 1 shared A. P. J. Vlaar· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

G. Vidarsson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

C. E. Geyer, H.-J. Chen, A. P. Bye, X. D. Manz, D. Guerra, T. G. Caniels, T. P. L. Bijl, G. R. Griffith, W. Hoepel, S. W. de Taeye, J. Veth, A. P. J. Vlaar, Amsterdam UMC COVID-19 Biobank, G. Vidarsson, H. J. Bogaard, , J. den Dunnen

The paper identifies SYK and PI3K inhibitors, particularly entospletinib, as effective in counteracting anti-spike IgG-induced hyperinflammation in severe COVID-19.

bioRxiv · Dec 20, 2022Immunology

Wall teichoic acids facilitate the release of toxins from the surface of Staphylococcus aureus.

T. Brignoli, E. J. Douglas, S. Duggan, O. G. Fagunloye, R. P. Adhikari, J. Aman, R. C. Massey

This study identifies wall teichoic acids (WTA) as essential for the release of cytolytic toxins from Staphylococcus aureus by altering the electrostatic charge of the cell envelope.

bioRxiv · Jan 31, 2022Microbiology

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

W. Hoepel, H.-J. Chen, S. Allahverdiyeva, X. Manz, J. Aman, P. Bonta, P. Brouwer, S. de Taeye, T. Caniels, K. van der Straten, K. Golebski, G. Griffith, R. Jonkers, M. Larsen, F. Linty, , J. den Dunnen

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients induces hyper-inflammatory responses in macrophages, leading to endothelial barrier breakdown and microvascular thrombosis.

bioRxiv · Jul 13, 2020Immunology

ZIKA VIRUS INFECTION DURING PREGNANCY AND INDUCED BRAIN PATHOLOGY IN BECLIN1-DEFICIENT MOUSE MODEL

M. K. Muthu Karuppan, C. R. Ojha, M. Rodriguez, J. Lapierre, J. Aman, F. Kashanchi, M. Toborek, M. Nair, N. El-Hage

This study investigates the role of Beclin1 in ZIKV infection during pregnancy, showing growth impairments and brain pathology in offspring of Beclin1-deficient mice.

bioRxiv · Nov 15, 2019 · PreprintImmunology

Therapeutic Treatment of Aerosolized Staphylococcal Enterotoxin B in Nonhuman Primates with two Monoclonal Antibodies

D. Verreault, J. Ennis, K. Whaley, S. Killeen, H. Karauzum, J. Aman, R. Holtsberg, L. Doyle-Meyers, P. Didier, L. Zeitlin, C. J. Roy

Two monoclonal antibodies were tested for therapeutic efficacy against aerosolized SEB in a nonhuman primate model, showing survival in treated animals compared to untreated controls.

bioRxiv · Sep 23, 2018 · PreprintImmunology