Author

M. Tolmasky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

M. S. Ramirez· 8 shared R. A. Bonomo· 6 shared M. R. Tuttobene· 4 shared B. Nishimura· 3 shared C. Pimentel· 3 shared G. M. Traglia· 3 shared T. Subils· 3 shared T. Tran· 3 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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8 shared papersMicrobiology

M. S. Ramirez

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

O. Wong, V. Mezcord, C. Lopez, G. M. Traglia, F. Pasteran, M. R. Tuttobene, A. Corso, M. Tolmasky, R. A. Bonomo, M. S. Ramirez

This study investigates the molecular mechanisms of cefiderocol resistance and antagonism with avibactam and sulbactam in carbapenem-resistant Acinetobacter strains.

bioRxiv · Mar 4, 2024 · PreprintMicrobiology

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance

O. d'Udekem d'Acoz, F. Hue, T. Ye, L. Wang, M. Leroux, L. Rajngewerc, T. Tran, K. Phan, M. S. Ramirez, W. Reisner, M. Tolmasky, R. Reyes Lamothe

This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.

bioRxiv · Sep 5, 2023 · PreprintMicrobiology

The Iron Content of Human Serum Albumin Modulates the Susceptibility of Acinetobacter baumannii to Cefiderocol

J. Escalante, B. Nishimura, M. R. Tuttobene, T. Subils, V. Mezcord, L. A. Actis, M. Tolmasky, R. A. Bonomo, M. S. Ramirez

This paper shows that human serum albumin (HSA) increases Acinetobacter baumannii resistance to cefiderocol by modulating iron uptake and beta-lactam resistance gene expression.

bioRxiv · Aug 24, 2022Microbiology

Impact of Human Serum Proteins on Susceptibility of Acinetobacter baumannii to Cefiderocol: role of iron transport

C. Le, C. Pimentel, F. Pasteran, M. R. Tuttobene, T. Subils, J. Escalante, B. Nishimura, S. Arriaga, A. Carranza, A. J. Vila, A. Corso, L. A. Actis, M. Tolmasky, R. A. Bonomo, M. S. Ramirez

The paper shows that human serum and its components increase Acinetobacter baumannii resistance to cefiderocol by altering iron uptake and beta-lactam resistance genes.

bioRxiv · Aug 18, 2021Microbiology

Interplay between meropenem and human serum albumin on expression of carbapenem resistance genes and natural competence in Acinetobacter baumannii

C. Pimentel, C. Le, M. R. Tuttobene, T. Subils, B. Nishimura, G. M. Traglia, F. Perez, K. M. Papp-Wallace, R. A. Bonomo, M. Tolmasky, M. S. Ramirez

This study shows that human serum albumin and meropenem together enhance natural transformation and gene expression in Acinetobacter baumannii, potentially promoting resistance and evolution.

bioRxiv · May 14, 2021Microbiology

Cerebrospinal fluid (CSF) boosts metabolism and virulence expression factors in Acinetobacter baumannii

J. Martinez, C. Razo-Gutierrez, C. Li, R. Courville, C. Pimentel, C. Liu, S. Fung, A. J. Vila, P. Shahrestani, V. Jimenez, M. Tolmasky, S. A. Becka, K. M. Papp-Wallace, R. A. Bonomo, A. Soler, , M. S. Ramirez

This study shows that cerebrospinal fluid (CSF) enhances virulence factor expression and metabolic processes in low-virulence Acinetobacter baumannii strains.

Scientific Reports · Feb 26, 2021Peer-reviewedMicrobiology

Restoration of Susceptibility to Amikacin by 8-Hydroxyquinoline Analogs Complexed to Zinc

J. Magallon, K. Chiem, T. Tran, V. Jimenez, M. S. Ramirez, M. Tolmasky

This study evaluates 8-hydroxyquinoline analogs complexed with zinc to restore amikacin susceptibility in AAC(6)-Ib-producing Acinetobacter baumannii strains.

bioRxiv · Apr 5, 2019Microbiology

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain

G. M. Traglia, K. Place, C. Dotto, J. S. Fernandez, C. dos Santos Bahiense, A. Soler-Bistue, A. Iriarte, M. Tolmasky, R. A. Bonomo, R. Melano, M. S. Ramirez

This study shows that natural transformation enables Acinetobacter baumannii to acquire antibiotic resistance genes from Klebsiella pneumoniae, contributing to the emergence of multi-drug-resistant strains.

bioRxiv · Apr 26, 2018Microbiology

Identification of a Small Molecule Inhibitor of the Aminoglycoside 6’-N-Acetyltransferase Type Ib [AAC(6’)-Ib] Using Mixture-Based Combinatorial Libraries

T. Tran, K. Chiem, S. Jani, B. Arivett, D. Lin, R. Lad, V. Jimenez, M. Farone, G. Debevec, R. Santos, M. Giulianotti, C. Pinilla, M. Tolmasky

The paper identifies a small molecule inhibitor of AAC(6’)-Ib using combinatorial libraries and evaluates its efficacy against antibiotic-resistant bacteria.

bioRxiv · Oct 4, 2017Microbiology