IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma
B. Curren, T. Ahmed, D. R. Howard, A. Ullah, I. Sebina, R. Rashid, A. A. Sikder, A. Bissell, S. Ngo, D. Jackson, M. Toussaint, M. Edwards, S. Johnston, H. J. McSorley, S. Phipps
This study identifies IL-33 as a key driver of neutrophilic inflammation and NETosis in rhinovirus-induced asthma exacerbations, showing that blocking IL-33 reduces exacerbation severity.
bioRxiv · Nov 7, 2022Immunology