Author

D. R. Howard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:metagenomics· 2

Frequent Co-Authors

A. Bissell· 3 shared B. Curren· 3 shared I. Sebina· 3 shared S. Phipps· 3 shared T. Ahmed· 3 shared M. A. A. Sikder· 2 shared M. A. Ullah· 2 shared M. M. Rahman· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. Bissell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling

B. Curren, T. Ahmed, R. B. Rashid, I. Sebina, M. A. A. Sikder, D. R. Howard, M. Alorro, M. A. Ullah, A. Bissell, M. M. Rahman, M. A. Pearen, G. A. Ramm, A. Varelias, S. Rose-John, P. O. Cuiv, , S. Phipps

This study shows that a maternal high-fat diet increases neonatal systemic inflammation and predisposes to infant lung disease via neutrophil-mediated IL-6 trans-signaling.

bioRxiv · Mar 13, 2024Immunology

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

M. A. A. Sikder, R. B. Rashid, T. Ahmed, I. Sebina, D. R. Howard, M. A. Ullah, M. M. Rahman, J. P. Lynch, B. Curren, R. B. Werder, J. Simpson, A. Bissell, M. Morrison, C. Walpole, K. J. Radford, , S. Phipps

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

bioRxiv · Jan 5, 2023Immunology

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

B. Curren, T. Ahmed, D. R. Howard, A. Ullah, I. Sebina, R. Rashid, A. A. Sikder, A. Bissell, S. Ngo, D. Jackson, M. Toussaint, M. Edwards, S. Johnston, H. J. McSorley, S. Phipps

This study identifies IL-33 as a key driver of neutrophilic inflammation and NETosis in rhinovirus-induced asthma exacerbations, showing that blocking IL-33 reduces exacerbation severity.

bioRxiv · Nov 7, 2022Immunology