Author

H. J. McSorley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:proteomics· 2 Assay:protein structure· 1

Frequent Co-Authors

A. A. Sikder· 1 shared A. Bissell· 1 shared A. Jamwal· 1 shared A. Ogunkanbi· 1 shared A. Ullah· 1 shared B. Curren· 1 shared B. H. K. Chan· 1 shared C. Chauche· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperImmunology

A. A. Sikder

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4 papers

Recent·Most cited

Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI

A. Jamwal, F. Colomb, H. J. McSorley, M. K. Higgins

The paper determines the structure of HpARI bound to mouse IL-33, showing how HpARI blocks IL-33 signaling by competing with its receptor ST2.

bioRxiv · Aug 10, 2023 · PreprintMicrobiology

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

B. Curren, T. Ahmed, D. R. Howard, A. Ullah, I. Sebina, R. Rashid, A. A. Sikder, A. Bissell, S. Ngo, D. Jackson, M. Toussaint, M. Edwards, S. Johnston, H. J. McSorley, S. Phipps

This study identifies IL-33 as a key driver of neutrophilic inflammation and NETosis in rhinovirus-induced asthma exacerbations, showing that blocking IL-33 reduces exacerbation severity.

bioRxiv · Nov 7, 2022Immunology

IL-17A promotes epithelial cell IL-33 production during nematode lung migration

J. Ajendra, S. Pearson, J. Parkinson, B. H. K. Chan, H. J. McSorley, T. E. Sutherland, J. E. Allen

This study shows IL-17A promotes IL-33 production in lung epithelial cells during nematode infection, independent of IFN-gamma suppression.

bioRxiv · Nov 3, 2022 · PreprintImmunology

A truncated form of HpARI stabilises IL-33, amplifying responses to the cytokine.

C. Chauche, F. Vacca, S. L. Chia, J. Richards, W. F. Gregory, A. Ogunkanbi, M. Wear, H. J. McSorley

This study shows that a truncated form of HpARI stabilizes IL-33, enhancing immune responses to allergens and infections.

bioRxiv · Apr 13, 2020Immunology