S. Phipps

A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling

This study shows that a maternal high-fat diet increases neonatal systemic inflammation and predisposes to infant lung disease via neutrophil-mediated IL-6 trans-signaling.

Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma.

This study shows that combining DP2 antagonism with corticosteroids reduces the effectiveness of DP2 antagonism in treating chronic asthma by suppressing PGD2 and IFN-γ production.

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

This study identifies IL-33 as a key driver of neutrophilic inflammation and NETosis in rhinovirus-induced asthma exacerbations, showing that blocking IL-33 reduces exacerbation severity.

Synergism and antagonism of bacterial-viral co-infection in the upper respiratory tract

This study investigates bacterial-viral co-infection dynamics in the upper respiratory tract, finding both synergistic and antagonistic effects between pneumococci and RSV-like viruses.