Long-term cytotoxic NK cells with broad anti-tumour capacity proliferate selectively, without exhaustion, after BCG priming and extremely low doses of cytokines
M.-J. Felgueres, G. Esteso, A. Garcia-Jimenez, A. Dopazo, L. Martinez-Pineiro, H. T. Reyburn, M. Vales-Gomez
This paper describes a method to generate long-lived, cytotoxic NK cells with broad anti-tumour activity using BCG priming and low-dose cytokines, without cell sorting or exhaustion.
bioRxiv · Jun 7, 2023 · PreprintImmunology