T. Ranganath

NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells

This study identifies NKp30:B7-H6 and NKG2D:MICB/ULBP2 as receptor-ligand pairs that contribute to NK cell recognition of HIV-infected cells.

Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.

This study shows that HIV/ARV-exposed uninfected infants have reduced T cell receptor diversity and altered immune development, increasing infection risk.

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

CyTOF analysis identifies unusual immune cells in urine of BCG-treated bladder cancer patients

The paper uses CyTOF to identify a novel immune cell population in urine of BCG-treated bladder cancer patients, linking it to inflammatory response and potential treatment risk.

Characterization of the impact of daclizumab beta on circulating natural killer cells by mass cytometry

This study uses mass cytometry to analyze how daclizumab beta affects NK cell phenotypes in RMS patients, showing distinct changes in CD56bright and CD56dim subsets.

TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells

This study shows that TIGIT is upregulated on NK cells in untreated HIV+ individuals and marks a functional, mature NK cell subset with enhanced responses to HIV-infected targets.