Structure-based Classification of Tauopathies
Yang Shi, Wenjuan Zhang, Yang Yang, Alexey G. Murzin, Benjamin Falcon, Abhay Kotecha, M. van Beers, Airi Tarutani, Fuyuki Kametani, Holly J. Garringer, Rubén Vidal, Grace I. Hallinan, Tammaryn Lashley, Yuko Saito, Shigeo Murayama, , Sjors H. W. Scheres
Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.
Nature · Sep 29, 2021Peer-reviewedNeuroscience✦ In-depth digest