Radiotherapy and cisplatin increase immunotherapy efficacy by enabling local and systemic intratumoral T-cell activity
P. Kroon, E. Frijlink, V. Iglesias-Guimarais, A. Volkov, M. van Buuren, T. N. Schumacher, M. Verheij, J. Borst, I. Verbrugge
This study shows radiotherapy and cisplatin enhance immunotherapy efficacy in breast cancer by overcoming PD-1-independent T-cell suppression in the tumor microenvironment.
bioRxiv · Jun 29, 2018Cancer Biology