Author

I. Verbrugge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. Frijlink· 2 shared J. Borst· 2 shared T. N. Schumacher· 2 shared A. Fowler· 1 shared A. J. Morris· 1 shared A. Mazzocca· 1 shared A. Menegakis· 1 shared A. Perrakis· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

E. Frijlink

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Author profile →

3 papers

Recent·Most cited

Patient phenotypes and their relation to TNFα signaling and immune cell composition in critical illness and autoimmune disease

V. Krishna, H. Banie, N. Conceicao-Neto, Y. Murata, I. Verbrugge, V. Trifonov, R. Martinez, V. Murali, Y.-c. Lee, R. D. May, I. Najera, A. Fowler, C. K. F. Li

The paper identifies a hyper-inflammatory phenotype linked to TNF signaling and mature neutrophils in critical illness and autoimmune disease using machine learning and patient data.

bioRxiv · Oct 30, 2023 · PreprintImmunology

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

E. Matas-Rico, E. Frijlink, I. van der Haar Avila, A. Menegakis, M. van Zon, A. J. Morris, J. Koster, F. Salgado-Polo, S. de Kivit, T. Lanca, A. Mazzocca, Z. Johnson, J. Haanen, T. N. Schumacher, A. Perrakis, , W. H. Moolenaar

This study shows that ATX secreted by melanoma cells repels CD8+ T cells, reducing their infiltration into tumors and impairing anti-tumor immunity.

bioRxiv · Feb 26, 2020Cancer Biology

Radiotherapy and cisplatin increase immunotherapy efficacy by enabling local and systemic intratumoral T-cell activity

P. Kroon, E. Frijlink, V. Iglesias-Guimarais, A. Volkov, M. van Buuren, T. N. Schumacher, M. Verheij, J. Borst, I. Verbrugge

This study shows radiotherapy and cisplatin enhance immunotherapy efficacy in breast cancer by overcoming PD-1-independent T-cell suppression in the tumor microenvironment.

bioRxiv · Jun 29, 2018Cancer Biology