Author

M. van der Vaart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:zebrafish· 3 Assay:imaging· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. Varela· 4 shared A. H. Meijer· 3 shared R. Zhang· 2 shared A. Banducci-Karp· 1 shared A. Groenewoud· 1 shared A. Meijer· 1 shared C. Sarantaris· 1 shared G. Forn-Cuni· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

M. Varela

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Author profile →

4 papers

Recent·Most cited

DRAM1 promotes antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages

A. Banducci-Karp, J. Xie, S. A. G. Engels, C. Sarantaris, M. Varela, A. H. Meijer, M. van der Vaart

This study shows DRAM1 facilitates antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages by promoting vesicle acidification and fusion.

bioRxiv · Oct 25, 2022 · PreprintImmunology

Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages

R. Zhang, M. Varela, G. Forn-Cuni, V. Torraca, M. van der Vaart, A. Meijer

This study shows that Dram1 deficiency in zebrafish increases susceptibility to Mycobacterium marinum infection by impairing phagosome maturation and inducing pyroptotic cell death in macrophages.

bioRxiv · Jun 7, 2019Immunology

Extracellular mycobacterial DNA drives disease progression by triggering Caspase-11-dependent pyroptosis of infected macrophages

M. Varela, M. van der Vaart, A. Groenewoud, A. H. Meijer

The paper shows extracellular mycobacterial DNA triggers Caspase-11-dependent pyroptosis in macrophages, promoting TB progression through an Asc-independent pathway.

bioRxiv · Feb 17, 2019 · PreprintImmunology

The selective autophagy receptors Optineurin and p62 are both required for innate host defense against mycobacterial infection

R. Zhang, M. Varela, W. Vallentgoed, M. van der Vaart, A. H. Meijer

This study shows that Optineurin and p62 are required for autophagic host defense against mycobacterial infection in zebrafish.

bioRxiv · Sep 12, 2018Immunology