Author

A. Groenewoud

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. B. Snaar· 2 shared J. Yin· 2 shared M. C. Gelmi· 2 shared M. J. Jager· 2 shared A. G. Jochemsen· 1 shared A. H. Meijer· 1 shared D. Decaudin· 1 shared E. B. E. Snaar-Jagalska· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

E. B. Snaar

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Author profile →

5 papers

Recent·Most cited

Mechano-signaling of prostate tumor initiating cells facilitates their tropism to stiff metastatic niche

L. Chen, G. Zhao, M. De Menna, S. Coppola, A. Groenewoud, N. Landman, S. Schieven, G. N. Thalmann, T. Schmidt, J. de Vrie, M. Kruithof-de Julio, E. B. Snaar

The paper shows that mechanotransduction via TAZ and cytoskeletal tension promotes prostate cancer stem cell metastasis and identifies a YAP/TAZ inhibitor as a potential therapeutic target.

bioRxiv · Aug 28, 2023 · PreprintCancer Biology

Melanin enhances metastatic melanoma colonization by inhibiting ferroptosis

A. Groenewoud, G. Zhou, M. C. Gelmi, J. Yin, G. E. M. Lamers, R. van Doorn, R. M. Verdijk, M. J. Jager, F. B. Engel, E. B. Snaar

This study shows melanin protects melanoma cells from ferroptosis, enhancing metastasis, and suggests targeting melanin and ferroptosis could improve treatment of metastatic melanoma.

bioRxiv · Apr 3, 2023 · PreprintCancer Biology

Patient-derived zebrafish xenograft models reveal ferroptosis as a fatal and druggable weakness in metastatic uveal melanoma

A. Groenewoud, J. Yin, M. C. Gelmi, S. Alsafadi, F. Nemati, D. Decaudin, S. Roman-Roman, H. Kalirai, S. E. Coupland, A. G. Jochemsen, M. J. Jager, E. Snaar-Jagalska

The paper develops a zebrafish xenograft model of metastatic uveal melanoma and identifies ferroptosis as a druggable vulnerability in tumors with BAP1 loss.

bioRxiv · Oct 26, 2021 · PreprintCancer Biology

XePhIR: The zebrafish Xenograft Phenotype Interactive Repository

A. Groenewoud, G. Forn-Cuni, F. Engel, E. B. E. Snaar-Jagalska

XePhIR provides a platform for sharing zebrafish xenograft data to improve reproducibility and visibility of cancer research using this model.

bioRxiv · Sep 13, 2021 · PreprintCancer Biology

Extracellular mycobacterial DNA drives disease progression by triggering Caspase-11-dependent pyroptosis of infected macrophages

M. Varela, M. van der Vaart, A. Groenewoud, A. H. Meijer

The paper shows extracellular mycobacterial DNA triggers Caspase-11-dependent pyroptosis in macrophages, promoting TB progression through an Asc-independent pathway.

bioRxiv · Feb 17, 2019 · PreprintImmunology