A. H. Meijer

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria

This study screens kinase inhibitors to identify host-directed therapies effective against intracellular bacteria Salmonella Typhimurium and Mycobacterium tuberculosis.

DRAM1 promotes antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages

This study shows DRAM1 facilitates antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages by promoting vesicle acidification and fusion.

An arginase 2 promoter transgenic illuminates anti-inflammatory signalling in zebrafish

This study develops a zebrafish transgenic model to investigate anti-inflammatory signaling, showing arginase 2 is expressed in neutrophils during immune challenges.

Transition of Vibrio cholerae through a natural host induces resistance to environmental changes

This study shows that Vibrio cholerae undergoes morphological changes during environmental transitions, which are critical for its ability to colonize host tissues.

Dram1 confers resistance to Salmonella infection

This study shows Dram1 enhances resistance to Salmonella infection by promoting LAP, a phagocytic autophagy mechanism, through ROS production and xenophagy.

Glucocorticoid treatment exacerbates mycobacterial infection by reducing the phagocytic capacity of macrophages

This study shows glucocorticoids reduce macrophage phagocytosis, increasing bacterial burden in a zebrafish tuberculosis model, which may explain increased susceptibility to tuberculosis in humans.

RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this Toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection

This study uses RNA-seq to analyze tlr2 mutant zebrafish and finds TLR2 plays a role in transcriptional control, metabolism, and defense against Mycobacterium marinum.

Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish

The study shows that Cxcr3.3, an atypical chemokine receptor in zebrafish, regulates macrophage migration by scavenging ligands that would otherwise activate Cxcr3.2, a conventional receptor involved in immune response.

The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils

This study shows that S. aureus uses autophagy to create an intracellular niche in neutrophils, while p62-mediated autophagy protects the host.

RNAseq profiling of leukocyte populations in zebrafish larvae reveals a cxcl11 chemokine gene as a marker of macrophage polarization during mycobacterial infection.

The paper identifies cxcl11aa as a marker of M1 macrophage polarization in zebrafish during mycobacterial infection using RNAseq profiling of sorted immune cell populations.

Extracellular mycobacterial DNA drives disease progression by triggering Caspase-11-dependent pyroptosis of infected macrophages

The paper shows extracellular mycobacterial DNA triggers Caspase-11-dependent pyroptosis in macrophages, promoting TB progression through an Asc-independent pathway.

Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration

The paper shows glucocorticoids inhibit macrophage differentiation to a pro-inflammatory phenotype but not their migration in a zebrafish wound model.

The selective autophagy receptors Optineurin and p62 are both required for innate host defense against mycobacterial infection

This study shows that Optineurin and p62 are required for autophagic host defense against mycobacterial infection in zebrafish.

Hif-1alpha induced expression of Il-1beta protects against mycobacterial infection in zebrafish

The paper shows that Hif-1alpha increases Il-1beta expression in zebrafish macrophages, enhancing nitric oxide production and protecting against Mycobacterium marinum infection.